Beyond oxidative stress: Emerging molecular mechanisms and translational perspectives in environmental toxicant-induced hematotoxicity
DOI:
https://doi.org/10.61511/ajteoh.v4i1.2026.3962Keywords:
biomakers, environmental toxicants, hematopoietic stem cells, hematotoxicity, reprogramming ferroptosisAbstract
Background: Environmental toxicants, including heavy metals, pesticides, particulate air pollutants, per- and polyfluoroalkyl substances (PFAS), and microplastics, are increasingly recognized as major contributors to hematological disorders. Although oxidative stress has traditionally been regarded as the principal mechanism underlying environmental toxicant-induced hematotoxicity, emerging evidence suggests that additional molecular pathways contribute substantially to hematopoietic injury. This review examines the evolving molecular mechanisms of environmental toxicant-induced hematotoxicity beyond the conventional oxidative stress paradigm and explores their translational implications. Methods: Literature was retrieved from PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar and synthesized through a structured narrative review. Evidence published primarily between 2020 and 2026 was critically evaluated and organized into thematic areas including oxidative stress, mitochondrial dysfunction, ferroptosis, pyroptosis, epigenetic reprogramming, immunometabolic dysregulation, hematopoietic stem-cell dysfunction, biomarker discovery, multi-omics technologies, artificial intelligence, and precision hematology. Findings: Environmental toxicant-induced hematotoxicity is mediated by a complex network of interacting molecular pathways rather than oxidative stress alone. Emerging evidence highlights important roles for mitochondrial dysfunction, ferroptosis, pyroptosis, epigenetic reprogramming, immunometabolic dysregulation, and hematopoietic stem-cell (HSC) impairment in regulating blood-cell homeostasis and bone marrow integrity. These pathways interact extensively with oxidative stress and contribute to disease heterogeneity, chronic toxicity, and variable clinical outcomes. Advances in multi-omics technologies and artificial intelligence further provide opportunities for biomarker discovery, improved risk assessment, and early disease detection. Conclusion: Environmental toxicant-induced hematotoxicity should be viewed as a systems-level disorder arising from coordinated interactions among multiple molecular pathways. Integrating mechanistic insights with multi-omics technologies, artificial intelligence (AI), and precision hematology may improve disease prediction, biomarker development, early diagnosis, and targeted intervention strategies. Novelty/Originality of this article: This review moves beyond the traditional oxidative stress paradigm by integrating emerging molecular mechanisms into a systems hematotoxicology framework for understanding environmental toxicant-induced hematological injury. It synthesizes evidence on mitochondrial dysfunction, ferroptosis, pyroptosis, epigenetic reprogramming, immunometabolic dysregulation, and hematopoietic stem-cell dysfunction while highlighting their translational relevance for biomarker discovery, multi-omics research, artificial intelligence, and precision hematology. This integrated perspective remains largely absent from conventional reviews that examine these mechanisms independently.
References
Abbas, Q., Jeong, W., & Lee, S. W. (2025). Explainable ai in clinical decision support systems: a meta-analysis of methods, applications, and usability challenges. Healthcare, 13(17), 2154. https://doi.org/10.3390/healthcare13172154
Adegbola, P. I., & Adetutu, A. (2024). Genetic and epigenetic modulations in toxicity: The two-sided roles of heavy metals and polycyclic aromatic hydrocarbons from the environment. Toxicology Reports, 12, 502–519. https://doi.org/10.1016/j.toxrep.2024.04.010
Afzal, S., Abdul Manap, A. S., Attiq, A., Albokhadaim, I., Kandeel, M., & Alhojaily, S. M. (2023). From imbalance to impairment: The central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration. Frontiers in Pharmacology, 14, 1269581. https://doi.org/10.3389/fphar.2023.1269581
Amini, H., & Wang, J. (2026). Decoding disease complexity: Multi-Omics integration and AI in precision medicine. The Journal of Precision Medicine: Health and Disease, 100047. https://doi.org/10.1016/j.premed.2026.100047
Anastasiou, I. A., Kounatidis, D., Vallianou, N. G., Rebelos, E., Karampela, I., & Dalamaga, M. (2026). Clonal Hematopoiesis of indeterminate potential and cardiometabolic disease: Challenges, controversies and future perspectives. International Journal of Molecular Sciences, 27(1), 233. https://doi.org/10.3390/ijms27010233
Anwar, S., Sarwar, T., Khan, A. A., & Rahmani, A. H. (2025). Therapeutic applications and mechanisms of superoxide dismutase (sod) in different pathogenesis. Biomolecules, 15(8), 1130. https://doi.org/10.3390/biom15081130
Arauna, D., Navarrete, S., Albala, C., Wehinger, S., Pizarro-Mena, R., Palomo, I., & Fuentes, E. (2024). Understanding the role of oxidative stress in platelet alterations and thrombosis risk among frail older adults. Biomedicines, 12(9), 2004. https://doi.org/10.3390/biomedicines12092004
Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. (2022). Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: role of nanoparticle-based drug delivery systems in clinical translation. Antioxidants, 11(2), 408. https://doi.org/10.3390/antiox11020408
Aslam, N., Li, Q., Bashir, S., Yuan, L., Qiao, L., & Li, W. (2024). Integrated review of transcriptomic and proteomic studies to understand molecular mechanisms of rice’s response to environmental stresses. Biology, 13(9), 659. https://doi.org/10.3390/biology13090659
Balakrishnan, V. K., Rajkumar, A., Ganesh, M. K. G., Kovvuri, H. R., Selvam, D., Krishnamurthy, P., Sundaram, S., Periandavan, K., Ramesh, S., Ramamurthy, M. T., & Rajasekaran, N. S. (2026). Redox imbalance and genetic mutations in heart failure: synergistic mechanisms and therapeutic strategies. Genes, 17(2), 225. https://doi.org/10.3390/genes17020225
Bearth, A., Kopainsky, B., Jones, L. B., Vist, G. E., Husøy, T., Svendsen, C., Whaley, P., Hoffmann, S., Ames, H. M., Solstad, G., Bloch, D., Čavoški, A., Chiu, W. A., Davenport, M., Davies, H. G., Giusti, A., Hartung, T., Kwon, S., Osborne, O. J., Rooney, A. A., Rousselle, C., Sass, J. B., Wright, F. A., & Mathisen, G. H. (2025). Exploring experiences of the regulatory toxicology system: System-level promoters and inhibitors of new approach methodologies. Archives of Toxicology, 99(12), 4909–4930. https://doi.org/10.1007/s00204-025-04168-z
Benam, S. R., Wang, X., Maleknia, S., Kapur, R., & Shahbazi, R. (2025). Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communication. Molecular Therapy, 33(11), 5704–5720. https://doi.org/10.1016/j.ymthe.2025.08.020
Boini, A., Grasso, V., Taher, H., & Gumbs, A. A. (2025). Artificial intelligence and the impact of multiomics on the reporting of case reports. World Journal of Clinical Cases, 13(15), 101188. https://doi.org/10.12998/wjcc.v13.i15.101188
Cannarella, R., Howard, S., Calogero, A. E., & Heindel, J. J. (2026). Reducing exposure to non-persistent endocrine-disrupting chemicals and their impact on human health: Evidence from dietary, behavioral, and residential interventions. Ecotoxicology and Environmental Safety, 318, 120272. https://doi.org/10.1016/j.ecoenv.2026.120272
Cardoso-Vera, J. D., Islas-Flores, H., Pérez-Alvarez, I., & Díaz-Camal, N. (2024). Evidence of oxidative stress as a mechanism of pharmaceutical-induced toxicity in amphibians. Antioxidants, 13(11), 1399. https://doi.org/10.3390/antiox13111399
Cheng, Y., Zhao, Y., Chen, C., & Zhang, F. (2025). Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions. MedComm, 6(9), e70241. https://doi.org/10.1002/mco2.70241
Chi, H. (2022). Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology. Cellular and Molecular Immunology, 19(3), 299–302. https://doi.org/10.1038/s41423-022-00840-x
Chowdhury, S., Sarkar, S., Das, A., Kar, K., & Chakraborty, P. (2026). Omics-based profiling of immune cell death in autoimmunity and inflammation. Cell Death, 2(1), 100007. https://doi.org/10.1016/j.celld.2026.100007
Chronopoulos, J., Hajishengallis, G., & Chavakis, T. (2026). Bone marrow rewired: Trained immunity and clonal hematopoiesis in metabolic disease. Metabolism, 180, 156603. https://doi.org/10.1016/j.metabol.2026.156603
Crépet, A., Quénel, P., Garric, J., Kaufmann, A., Bonmatin, J.-M., Duché, P., Mathieu, A., Carsique, M., Jean, J., Sanders, P., Cravedi, J.-P., Schuler, M., & Barouki, R. (2025). Integration of the exposome concept into health risk assessments: A challenge for health safety agencies. Environmental Research, 286, 123036. https://doi.org/10.1016/j.envres.2025.123036
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025). Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications. Acta Pharmaceutica Sinica B, 15(1), 15–34. https://doi.org/10.1016/j.apsb.2024.10.004
Diaconescu, I. B., Dumitru, A. V., Tataru, C. P., Toader, C., Șerban, M., Covache-Busuioc, R.-A., & Eva, L. (2025). From Electron Imbalance to Network Collapse: Decoding the Redox Code of Ischemic Stroke for Biomarker-Guided Precision Neuroprotection. International Journal of Molecular Sciences, 26(22), 10835. https://doi.org/10.3390/ijms262210835
Dixon, S. J., & Olzmann, J. A. (2024). The cell biology of ferroptosis. Nature Reviews. Molecular Cell Biology, 25(6), 424–442. https://doi.org/10.1038/s41580-024-00703-5
Domingo, J. L. (2026). Artificial intelligence revolution in toxicology: Clinical precision, global equity, and the 2030 roadmap. Toxicology Letters, 418, 111871. https://doi.org/10.1016/j.toxlet.2026.111871
Edwin, E., & Jayaprakash, N. (2026). Inflammation-Driven Multiorgan Dysfunction: Biomarker-Guided Diagnosis, Mechanistic Insights and Emerging Precision Therapeutic Strategies. Advances in Biomarker Sciences and Technology. https://doi.org/10.1038/s41580-024-00703-5
Fan, B.-L., Chen, L.-H., Chen, L.-L., & Guo, H. (2025). Integrative Multi-Omics Approaches for Identifying and Characterizing Biological Elements in Crop Traits: Current Progress and Future Prospects. International Journal of Molecular Sciences, 26(4), 1466. https://doi.org/10.3390/ijms26041466
Fang, H., Fang, G., Chen, D., Chang, H., Yang, M., Zhang, H., Jiang, Y., Cai, Y., Hu, Z., & Peng, X.-E. (2026). The association of environmental toxicants exposure with cardiovascular disease risk: A comprehensive analysis from population to molecular mechanism. Ecotoxicology and Environmental Safety, 309, 119562. https://doi.org/10.1016/j.ecoenv.2025.119562
Felekkis, K., Pieri, M., & Papaneophytou, C. (2023). Exploring the Feasibility of Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Osteoarthritis: Challenges and Opportunities. International Journal of Molecular Sciences, 24(17), 13144. https://doi.org/10.3390/ijms241713144
Fry, B. G., Johnstone, K., & Pizzino, S. (2026). Beyond Blast Injury: Occupational Hygiene, Safety, and Toxicology Considerations for Mixed-Metal and Energetic-Chemical Exposures to Explosive Ordnance Disposal Personnel. Toxics, 14(5), 379. https://doi.org/10.3390/toxics14050379
Garcia-Llorens, G., El Ouardi, M., & Valls-Belles, V. (2025). Oxidative Stress Fundamentals: Unraveling the Pathophysiological Role of Redox Imbalance in Non-Communicable Diseases. Applied Sciences, 15(18), 10191. https://doi.org/10.3390/app151810191
Germolec, D. R., Lebrec, H., Anderson, S. E., Burleson, G. R., Cardenas, A., Corsini, E., Elmore, S. E., Kaplan, B. L. F., Lawrence, B. P., Lehmann, G. M., Maier, C. C., McHale, C. M., Myers, L. P., Pallardy, M., Rooney, A. A., Zeise, L., Zhang, L., & Smith, M. T. (2022). Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification. Environmental Health Perspectives, 130(10), 105001. https://doi.org/10.1289/EHP10800
Grari, O., Khermach, A., Douzi, N., Chahid, N., Himri, A., Ouhnini, H., Berhili, A., Trougouty, N., Slaoui, M., Bensalah, M., & Seddik, R. (2026). Hematological impacts of environmental toxicants and sustainable strategies for prevention. Discover Environment, 4(1), 80. https://doi.org/10.1007/s44274-026-00594-7
Greene, L., Brain, J., Brown, B., Burley, C. V., Burton, E., Guan, Z., Myers, B., Ride, K., Sabatini, S., Siervo, M., Tadesse, A. W., Hing Tang, E. Y., Stephan, B. CM., & Dunne, J. (2026). Implementation of risk prediction and stratification approaches for ageing populations in Australian healthcare: A systematic review. The Lancet Regional Health - Western Pacific, 101910. https://doi.org/10.1016/j.lanwpc.2026.101910
Gwozdzinski, K., Pieniazek, A., & Gwozdzinski, L. (2026). Red Blood Cells in Normal and Pathological States: Redox Reactions of Hemoglobin. Molecules, 31(3), 444. https://doi.org/10.3390/molecules31030444
Ho, N. P.-Y., & Takizawa, H. (2022). Inflammation Regulates Haematopoietic Stem Cells and Their Niche. International Journal of Molecular Sciences, 23(3), 1125. https://doi.org/10.3390/ijms23031125
Hong, Y., Boiti, A., Vallone, D., & Foulkes, N. S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13(3), 312. https://doi.org/10.3390/antiox13030312
Hsu, C.-N., Hou, C.-Y., Chen, Y.-W., Chang-Chien, G.-P., Lin, S.-F., & Tain, Y.-L. (2025). Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention. Antioxidants, 14(10), 1205. https://doi.org/10.3390/antiox14101205
Jauhari, A., Singh, T., Carlisle, D. L., & Friedlander, R. M. (2026). Mitochondrial DNA: A molecular switch driving sterile neuroinflammation. Translational Neurodegeneration, 15(1), 5. https://doi.org/10.1186/s40035-026-00540-w
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024). Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Archives of Toxicology, 98(5), 1323–1367. https://doi.org/10.1007/s00204-024-03696-4
Kallai, A., Ungvari, A., Csaban, D., Orfi, Z., Lehoczki, A., Harasztdombi, J., Yabluchanskiy, A., Benyó, Z., Szappanos, Á., Tarantini, S., Sorond, F., Sótonyi, P., Andrikovics, H., & Ungvari, Z. (2025). Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: Implications for vascular contributions to cognitive impairment and dementia (VCID). GeroScience, 47(3), 2739–2775. https://doi.org/10.1007/s11357-025-01654-1
Khan, M., Mushtaq, M., Usman, M., Rahman, M. A. U., & Quan, G. (2025). Oxidative stress-induced cytotoxicity and the role of dietary antioxidants in farm animals: A review. Advances in Redox Research, 16, 100138. https://doi.org/10.1016/j.arres.2025.100138
Kim, M. E., Lim, Y., & Lee, J. S. (2025). Mitochondrial Dysfunction and Metabolic Reprogramming in Chronic Inflammatory Diseases: Molecular Insights and Therapeutic Opportunities. Current Issues in Molecular Biology, 47(12), 1042. https://doi.org/10.3390/cimb47121042
Kourti, M., & Kontoghiorghes, G. J. (2026). Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation. Antioxidants, 15(1), 15. https://doi.org/10.3390/antiox15010015
Koyama, H., Kamogashira, T., & Yamasoba, T. (2024). Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies. Antioxidants, 13(1), 76. https://doi.org/10.3390/antiox13010076
Kumar, M. A., Baba, S. K., Sadida, H. Q., Marzooqi, S. A., Jerobin, J., Altemani, F. H., Algehainy, N., Alanazi, M. A., Abou-Samra, A.-B., Kumar, R., Al-Shabeeb Akil, A. S., Macha, M. A., Mir, R., & Bhat, A. A. (2024). Extracellular vesicles as tools and targets in therapy for diseases. Signal Transduction and Targeted Therapy, 9(1), 27. https://doi.org/10.1038/s41392-024-01735-1
Kumbhar, S., Borude, S., & Deshmukh, R. (2026). Regulatory integration of new approach methodologies for human-relevant developmental and reproductive toxicity (DART) assessment: A systematic cross-sector review. Toxicology Reports, 16, 102257. https://doi.org/10.1016/j.toxrep.2026.102257
La Torre, G., Manai, M. V., Moretti, L., Vezza, F., Breccia, M., Cafolla, A., Bernardinetti, G., Leo, G., Stefanantoni, K., Pavan, A., & Sernia, S. (2024). Does Occupational Exposure to Chemicals/Carcinogens Affect the Hematological Parameters of Workers? Journal of Clinical Medicine, 13(21), 6317. https://doi.org/10.3390/jcm13216317
Lemanowicz, J., Kloska, S. M., Siwik-Ziomek, A., Kołaczyk, P., Lipińska, U. W., & Kloska, A. (2026). Biochemical Mechanisms of Cellular Stress Adaptation in the Pathogenesis of Chronic Diseases. Molecules, 31(9), 1381. https://doi.org/10.3390/molecules31091381
Li Pomi, F., Gammeri, L., Borgia, F., Di Gioacchino, M., & Gangemi, S. (2025). Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation. Antioxidants, 14(5), 555. https://doi.org/10.3390/antiox14050555
Li, Z., Zhang, H., Cheng, N., Li, H., Wang, X., & Shao, J. (2026). Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights. International Journal of Molecular Sciences, 27(9), 4043. https://doi.org/10.3390/ijms27094043
Liaqat, N., Li, X., Shahzadi, K., Khan, N., You, S., & Dai, X. (2026). Multi-omics analysis reveals organ-specific oxidative stress, apoptosis, and ferroptosis-related signatures in Macrobrachium rosenbergii under ammonia–hypoxia co-stress. Ecotoxicology and Environmental Safety, 318, 120280. https://doi.org/10.1016/j.ecoenv.2026.120280
Lin, M., Guo, J., Gu, Z., Tang, W., Tao, H., You, S., Jia, D., Sun, Y., & Jia, P. (2025). Machine learning and multi-omics integration: Advancing cardiovascular translational research and clinical practice. Journal of Translational Medicine, 23, 388. https://doi.org/10.1186/s12967-025-06425-2
Liu, Y., Pan, R., Ouyang, Y., Gu, W., Xiao, T., Yang, H., Tang, L., Wang, H., Xiang, B., & Chen, P. (2024). Pyroptosis in health and disease: Mechanisms, regulation and clinical perspective. Signal Transduction and Targeted Therapy, 9(1), 245. https://doi.org/10.1038/s41392-024-01958-2
Mafe, A. N., & Büsselberg, D. (2025). Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations. Journal of Xenobiotics, 16(1), 2. https://doi.org/10.3390/jox16010002
Malkots, B., Stamatiou, I., Panagiotopoulos, E., Inglezou, L., Sakka, V., Vrachiolias, G., Misidou, C., Spanoudakis, E., Kotsianidis, I., & Liapis, K. (2026). Clonal Hematopoiesis of Indeterminate Potential (CHIP): A Model of Mutation-Driven Thromboinflammation. Cancers, 18(9), 1326. https://doi.org/10.3390/cancers18091326
Matilla-Cabello, G., Remesal-Doblado, Á., Celebi-Cinar, M., Bodoque-García, A., Metin, F. B., Rezaei, A., Aftab, M., De los Santos-Fernández, R., Segovia-Zafra, A., Álvarez-Álvarez, I., Andrade, R. J., Cakan-Akdogan, G., Lucena, M. I., Konu, O., & Villanueva-Paz, M. (2026). Systematic review on genetic polymorphisms associated with idiosyncratic drug-induced liver injury (iDILI): iDILInet as an interactive visualization tool. Acta Pharmaceutica Sinica B, 16(6), 3603–3631. https://doi.org/10.1016/j.apsb.2026.03.030
Mesnage, R. (2025). Environmental Health Is Overlooked in Longevity Research. Antioxidants, 14(4), 421. https://doi.org/10.3390/antiox14040421
Młynarska, E., Bojdo, K., Bulicz, A., Hossa, K., Lisińska, W., Stasiak, P., Rysz, J., & Franczyk, B. (2026). Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases: A Review of Recent Advances and Therapeutic Implications. International Journal of Molecular Sciences, 27(2), 983. https://doi.org/10.3390/ijms27020983
Molla, G., & Bitew, M. (2025). The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies. Journal of Molecular Pathology, 6(3). https://doi.org/10.3390/jmp6030020
Moya-García, A. A., González-Jiménez, A., Moreno, F., Stephens, C., Lucena, M. I., & Ranea, J. A. G. (2022). Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology. Genes, 13(7), 1292. https://doi.org/10.3390/genes13071292
Neikirk, K., Harris, C., Le, H., Oliver, A., Shao, B., Liu, K., Beasley, H. K., Jamison, S., Ishimwe, J. A., Kirabo, A., & Hinton, A. (2024). Air pollutants as modulators of mitochondrial quality control in cardiovascular disease. Physiological Reports, 12(22), e70118. https://doi.org/10.14814/phy2.70118
Obeagu, E. I., Igwe, M. C., & Obeagu, G. U. (2024). Oxidative stress’s impact on red blood cells: Unveiling implications for health and disease. Medicine, 103(9), e37360. https://doi.org/10.1097/MD.0000000000037360
Okpoghono, J., Ugbebor, G. C., Igue, U. B., Onakurhefe, P., Ekayoda, O., Okonta, C. I., Atonuje, J. O., Eholor, F. O., Isoje, E. F., Okom, S. U., Tambe, E. B., Edewor, U. S., Obiebi, P. O., Orogu, J. O., Ukolobi, O., Ndego, C. E., Ometie, C. A., & Seigha, A. A. (2026). Influence of dietary patterns and oxidative stress in Chronic diseases. Clinical Nutrition Open Science, 68, 100688. https://doi.org/10.1016/j.nutos.2026.100688
Oktar, P. A., Babadağ, S., Güneş, M., Aydoğdu, G. Ö., & Ezer, Ü. (2026). Epigenetic regulatory role of KMT2C and its interaction with miRNAs: New perspectives in cancer biology. Gene Reports, 43, 102513. https://doi.org/10.1016/j.genrep.2026.102513
Panek, I., Liczek, M., Gabryelska, A., Rakoczy, I., Kuna, P., & Panek, M. (2023). Inflammasome signalling pathway in the regulation of inflammation – its involvement in the development and exacerbation of asthma and chronic obstructive pulmonary disease. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 40(4), 487–495. https://doi.org/10.5114/ada.2022.118077
Pathak, A., Anwer, T., Verma, A., Alhujaily, M., Alahmari, M., Alshahrani, S., Alam, N., Nomier, Y., & Alam, M. F. (2026). Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy. Precision Medication, 3(1), 100078. https://doi.org/10.1016/j.prmedi.2026.100078
Pierro, F., Fazio, M., Murdaca, G., Stagno, F., Gangemi, S., & Allegra, A. (2025). Oxidative Stress and Mitochondrial Dysfunction in Myelodysplastic Syndrome: Roles in Development, Diagnosis, Prognosis, and Treatment. International Journal of Molecular Sciences, 26(13), 6415. https://doi.org/10.3390/ijms26136415
Pognan, F., Beilmann, M., Boonen, H. C. M., Czich, A., Dear, G., Hewitt, P., Mow, T., Oinonen, T., Roth, A., Steger-Hartmann, T., Valentin, J.-P., Van Goethem, F., Weaver, R. J., & Newham, P. (2023). The evolving role of investigative toxicology in the pharmaceutical industry. Nature Reviews. Drug Discovery, 22(4), 317–335. https://doi.org/10.1038/s41573-022-00633-x
Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., & Wang, Z. (2022). Pyroptosis in inflammatory diseases and cancer. Theranostics, 12(9), 4310–4329. https://doi.org/10.7150/thno.71086
Remigante, A., & Morabito, R. (2023). Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases 2.0/3.0. International Journal of Molecular Sciences, 24(21), 16018. https://doi.org/10.3390/ijms242116018
Ripanda, A., Hossein, M., Rwiza, M. J., Nyanza, E. C., Selemani, J. R., Nkrumah, S., Bakari, R., Alfred, M. S., Machunda, R. L., & Vuai, S. A. H. (2025). Combatting toxic chemical elements pollution for Sub-Saharan Africa’s ecological health. Environmental Pollution and Management, 2, 42–62. https://doi.org/10.1016/j.epm.2025.01.003
Rix, B., Maduro, A. H., Bridge, K. S., & Grey, W. (2022). Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function. Frontiers in Physiology, 13, 1009160. https://doi.org/10.3389/fphys.2022.1009160
Rojas-Lemus, M., López-Valdez, N., González-Villalva, A., Bizarro-Nevares, P., Casarrubias-Tabarez, B., Cervantes-Valencia, M. E., Ustarroz-Cano, M., Rivera-Fernández, N., Anacleto-Santos, J., Chávez-Maya, F., Milán-Chávez, R., Morales-López, S., & Fortoul, T. I. (2026). The Dual Nature of Metals: Essential Nutrients and Environmental Contaminants. International Journal of Molecular Sciences, 27(9), 3815. https://doi.org/10.3390/ijms27093815
Rossin, D., Perrelli, M.-G., Lo Iacono, M., Rastaldo, R., & Giachino, C. (2025). Dynamic Interplay Between Autophagy and Oxidative Stress in Stem Cells: Implications for Regenerative Medicine. Antioxidants, 14(6), 691. https://doi.org/10.3390/antiox14060691
Ru, Q., Li, Y., Zhang, X., Chen, L., Wu, Y., Min, J., & Wang, F. (2025). Iron homeostasis and ferroptosis in muscle diseases and disorders: Mechanisms and therapeutic prospects. Bone Research, 13, 27. https://doi.org/10.1038/s41413-024-00398-6
Rubio, K., Hernández-Cruz, E. Y., Rogel-Ayala, D. G., Sarvari, P., Isidoro, C., Barreto, G., & Pedraza-Chaverri, J. (2023). Nutriepigenomics in Environmental-Associated Oxidative Stress. Antioxidants, 12(3), 771. https://doi.org/10.3390/antiox12030771
Salam, R. A., Dunlop, K. L. A., Gide, T. N., Wilmott, J., Smith, A., & Cust, A. E. (2025). Factors Associated With Implementation of Biomarker Testing and Strategies to Improve Its Clinical Uptake in Cancer Care: Systematic Review Using Theoretical Domains Framework. JCO Precision Oncology, 9, e2500063. https://doi.org/10.1200/PO-25-00063
Sarigiannis, D., Anesti, O., Papaioannou, N., Karakoltzidis, A., & Karakitsios, S. (2026). Computational standards and tools for exposome-wide association studies linking the human exposome with health outcomes. Environment International, 208, 110117. https://doi.org/10.1016/j.envint.2026.110117
Shen, Y., Zhang, P., Luo, J., Chen, S., Gu, S., Lin, Z., & Tang, Z. (2026). Artificial Intelligence Drives Advances in Multi-Omics Analysis and Precision Medicine for Sepsis. Biomedicines, 14(2), 261. https://doi.org/10.3390/biomedicines14020261
Shetty, S. S., D, D., S, H., Sonkusare, S., Naik, P. B., Kumari N, S., & Madhyastha, H. (2023). Environmental pollutants and their effects on human health. Heliyon, 9(9), e19496. https://doi.org/10.1016/j.heliyon.2023.e19496
Shevyrev, D., Tereshchenko, V., Berezina, T. N., & Rybtsov, S. (2023). Hematopoietic Stem Cells and the Immune System in Development and Aging. International Journal of Molecular Sciences, 24(6), 5862. https://doi.org/10.3390/ijms24065862
Sinha, B. K. (2025). Ferroptosis in Toxicology: Present and Future. International Journal of Molecular Sciences, 26(14), 6658. https://doi.org/10.3390/ijms26146658
Sokan-Adeaga, A. A., Sokan-Adeaga, M. A., Sokan-Adeaga, E. D., Oparaji, A. N., Edris, H., Tella, E. O., Balogun, F. A., Aledeh, M., & Amubieya, O. E. (2023). Environmental toxicants and health adversities: A review on interventions of phytochemicals. Journal of Public Health Research, 12(2), 22799036231181226. https://doi.org/10.1177/22799036231181226
Sule, R. O., Rivera, G. D. T., Vaidya, T., Gartrell, E., & Gomes, A. V. (2025). Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases. Antioxidants, 14(5), 604. https://doi.org/10.3390/antiox14050604
Tian, K., Yang, Y., Zhou, K., Deng, N., Tian, Z., Wu, Z., Liu, X., Zhang, F., & Jiang, Z. (2023). The role of ROS-induced pyroptosis in CVD. Frontiers in Cardiovascular Medicine, 10, 1116509. https://doi.org/10.3389/fcvm.2023.1116509
Wan, M., Simonin, E. M., Johnson, M. M., Zhang, X., Lin, X., Gao, P., Patel, C. J., Yousuf, A., Snyder, M. P., Hong, X., Wang, X., Sampath, V., & Nadeau, K. C. (2025). Exposomics: A review of methodologies, applications, and future directions in molecular medicine. EMBO Molecular Medicine, 17(4), 599–608. https://doi.org/10.1038/s44321-025-00191-w
Wang, K., Gan, M., Lei, Y., Liao, T., Li, J., Niu, L., Zhao, Y., Chen, L., Wang, Y., Zhu, L., & Shen, L. (2025). Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle. Cellular & Molecular Biology Letters, 30, 94. https://doi.org/10.1186/s11658-025-00771-1
Wang, T., Zhou, X., Yin, X., Zhang, A., Fan, Y., Chen, K., Tao, H., Tang, Z., Zhang, P., He, X., & Yin, L. (2025). From mitochondrial dysregulation to ferroptosis: Exploring new strategies and challenges in radioimmunotherapy (Review). International Journal of Oncology, 67(3), 76. https://doi.org/10.3892/ijo.2025.5781
Xu, K., Saaoud, F., Shao, Y., Lu, Y., Yang, Q., Jiang, X., Wang, H., & Yang, X. (2024). A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles. Redox Biology, 76, 103331. https://doi.org/10.1016/j.redox.2024.103331
Yang, B., Zhao, X., Yan, M., Jia, Y., Gu, Z., Hao, X., Wang, S., Li, Z., Zhao, X., Yang, Y., Wang, P., & Wang, W. (2026). Exposure to benzene, toluene and xylenes (BTX) and biological aging: Epidemiological evidence from Chinese industrial workers and mechanistic insights. Environment International, 208, 110124. https://doi.org/10.1016/j.envint.2026.110124
Yang, H., Niu, S., Guo, M., Liu, C., & Xue, Y. (2025). Toxic mechanisms of nanoparticle-induced ferroptosis and current research challenges: A critical review. Environmental Pollution, 387, 127328. https://doi.org/10.1016/j.envpol.2025.127328
Yang, H., Zhang, K., Wang, Y., Liu, S., Guo, Y., Liu, W., Sun, J., Zhang, Z., Zhang, S., Li, S., Zhao, Y., Liu, T., Liu, J., Pei, L., Xi, S., & Shi, P. (2026). Weighted network analysis of adverse outcome pathways decodes the multiscale mechanisms of environmental toxicity. Environmental Science and Ecotechnology, 29, 100663. https://doi.org/10.1016/j.ese.2026.100663
Yang, S., Zhang, T., Ge, Y., Niu, Y., Chen, M., Yin, L., Pu, Y., Chen, Z., Gu, Z., & Liang, G. (2026). Organ-on-a-chip toxicology. The Innovation, 7(6), 101252. https://doi.org/10.1016/j.xinn.2025.101252
Zafar, S., Hafeez, A., Shah, H., Mutiullah, I., Ali, A., Khan, K., Figueroa-González, G., Reyes-Hernández, O. D., Quintas-Granados, L. I., Peña-Corona, S. I., Kiyekbayeva, L. N., Butnariu, M., Tota, C.-E., Caunii, A., Büsselberg, D., Sharifi-Rad, J., & Leyva-Gómez, G. (2025). Emerging biomarkers for early cancer detection and diagnosis: Challenges, innovations, and clinical perspectives. European Journal of Medical Research, 30, 760. https://doi.org/10.1186/s40001-025-03003-6
Zayani, Z., Matinahmadi, A., Tavakolpournegari, A., & Bidooki, S. H. (2025). Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions. Stresses, 5(2), 26. https://doi.org/10.3390/stresses5020026
Zhang, H.-L., Sandai, D., Zhang, Z.-W., Song, Z.-J., Babu, D., Tabana, Y., Dahham, S. S., Adam Ahmed Adam, M., Wang, Y., Wang, W., Zhang, H.-L., Zhao, R., Barakat, K., Harun, M. S. R., Shapudin, S. N. M., & Lok, B. (2023). Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy. World Journal of Clinical Oncology, 14(12), 549–569. https://doi.org/10.5306/wjco.v14.i12.549
Zhang, Z., Wang, H., Kan, X., Zhang, X., Xu, S., Cai, J., & Guo, J. (2025). The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection. Frontiers in Pharmacology, 16, 1519273. https://doi.org/10.3389/fphar.2025.1519273
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Copyright (c) 2026 Esther Uyoyooghene Olokede, Favour Oluwadamilola Agboola, Jane Ifeyinwa Anatuanya, Ishola Abdul Dimeji
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