Glucose monitoring device by BioSENS digital innovation based on organic thin-film transistors to prevent early diabetes

Abstract

Background: Diabetes is now one of the most serious chronic diseases in the world, with a growing prevalence globally, including among adolescents. The goal of this research, to develop a non-invasive diagnostic method, is an urgent need. The invasive nature of traditional finger-prick blood glucose tests can discourage patients from regularly monitoring their glucose levels, leading to inadequate disease management and increasing the risk of diabetes complications. Methods: The method used is a non-invasive method that measures glucose levels in saliva through a smartphone app. This technology works using Organic Thin-Film Transistors (OTFTs) that integrate glucose oxidase, which reacts with saliva to produce hydrogen peroxide (H2O2), which then decomposes into proton ions and electron, triggering an electrical signal. This signal is then processed by a smart device. Findings: The BioSENS device enables non-invasive, needle-free blood glucose testing using OTFT-based saliva sensors. Early results show a consistent correlation with blood glucose, highlighting its feasibility. Strengths include painless use, affordability, and ease of use, though clinical validation and regulatory approval are still needed. Conclusion: Diabetes in Indonesia requires greater attention. The BioSENS innovation offers a promising non-invasive and accessible approach to support early prevention and monitoring. Novelty/Originality of this Article: With technological advances, the BioSENS device innovation is present as an effort to prevent diabetes early. BioSENS or Bio-Surveillance and Early Notification System, is a digital innovation based on OTFT with a non-invasive method that can measure glucose levels in saliva through a smartphone application. The BioSENS innovation is expected to receive full support from the government, healthcare workers, and related sectors, to support early detection and prevention of diabetes, thereby improving the nation's health and becoming a step forward in realizing Indonesia's golden generation.