​​​The impact of sedentary behavior on blood glucose levels in type 2 diabetes mellitus patients: A literature review

Authors

  • Lelyana Septia Damayanti Department of Nursing, Faculty of Nursing, Universitas Jember, Kalimantan Street No. 37, Bumi Tegalboto Campus, PO Box 159, Jember, East Java 68121, Indonesia

DOI:

https://doi.org/10.61511/jevnah.v2i1.2025.1735

Keywords:

sedentary behavior, type 2 diabetes mellitus, blood glucose control, physical activity interruptions, glycemic regulation

Abstract

Background: Sedentary behavior, characterized by prolonged sitting or lying down, is increasingly recognized as a major health risk, particularly for individuals with type 2 diabetes mellitus (T2DM). Previous studies have shown that sedentary lifestyles can exacerbate glucose control issues, leading to poor glycemic regulation and an increased risk of complications. This study aims to explore the relationship between sedentary behavior and blood glucose levels in T2DM patients, highlighting the potential benefits of interrupting sedentary time with physical activity. Methods: This research utilized a comprehensive literature review methodology, analyzing studies published over the past decade to assess the impact of sedentary behavior on glycemic control in T2DM patients. The review focused on both observational studies and experimental trials, employing data from clinical studies and patient monitoring. Findings: Prolonged sedentary behavior was found to be associated with worsening glucose control, including prolonged hyperglycemia and reduced euglycemia. Interrupting sedentary time with short bouts of physical activity (e.g., walking or light exercise) was shown to significantly improve glucose uptake in skeletal muscles, providing effects similar to anti-diabetic medications. Consistent and frequent interruption of sedentary behavior resulted in improved daily blood glucose control, potentially offering a non-pharmacological intervention for T2DM management. Conclusion: The study underscores the importance of reducing sedentary behavior in T2DM patients as a strategy to enhance blood glucose control and prevent complications. Regular physical activity interruptions can serve as a critical non-pharmacological intervention to manage and control blood glucose levels. Novelty/Originality of this article: This review contributes to the growing body of evidence on the health risks of sedentary behavior in T2DM patients, emphasizing the potential of simple lifestyle interventions to improve glycemic control, which has been insufficiently explored in previous literature. 

References

Ajao, T. (2019). Prevalence of obesity and type 2 diabetes with sedentary behaviors and their association across age groups in Canada. University of Lethbridge.

Bergouignan, A., Latouche, C., Heywood, S., Garce, M. S., Luthmoodoo, M., Medini, R., Natoli, A. K., Owen, N., Dunstan, D. W., & Kingwell, B. A. (2016). Frequent interruption of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Scientific Reports, 6, 32044. https://doi.org/10.1038/srep32044

Dugan, J. A. (2016). Exercise recommendation for patients with type 2. Journal of the American Academy of Physician Assistants, 29(1). https://doi.org/10.1097/01.jaa.0000475460.77476.f6

Fritschi, C., Park, H., Richardson, A., Park, C., Collins, E. G., Mermelstein, R., Riesche, L., & Quinn, L. (2016). Association between daily time spent in sedentary behavior and duration of hyperglycemia in type 2 diabetes. Biological Research for Nursing, 18(2), 160–166. https://doi.org/10.1177/1099800415579457

Henzon, J., Dunstan, D. W., Davies, M. J., & Yates, T. (2016). Sedentary behavior as a new behavioural target in the prevention and treatment of type 2 diabetes. Diabetes/Metabolism Research and Reviews, 32(1), 213–220. https://doi.org/10.1002/dmrr.2759

Holt, R. I. G., Cockram, C., Flyvbjerg, A., & Goldstein, B. J. (2010). Textbook of diabetes (4th ed.). Wiley-Blackwell.

Honda, T., Kishimoto, H., Mukai, N., Hata, J., Yoshida, D., Hirakawa, Y., Shibata, M., Ohara, T., Kumagai, S., & Ninomiya, T. (2019). Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama study. Journal of Diabetes Investigation, 10(3), 809–816. https://doi.org/10.1111/jdi.12957

International Diabetes Federation. (2019). IDF diabetes atlas (9th ed.). International Diabetes Federation.

Kementerian Kesehatan Republik Indonesia. (2018). Laporan Nasional Riskesdas 2018. Kementerian Kesehatan Republik Indonesia.

Marcal, I. R., Fernandes, B., Viana, A. A., & Ciolac, E. G. (2020). The urgent need for recommending physical activity for the management of diabetes during and beyond COVID-19 outbreak. Frontiers in Endocrinology, 11, 584642. https://doi.org/10.3389/fendo.2020.584642

Mujabi, M. F., & Yuniartika, W. (2018). Hubungan kadar gula darah dengan tingkat depresi dan aktivitas fisik pada penderita diabetes melitus. Jurnal Berita Ilmu Keperawatan, 11(2), 153–159. https://doi.org/10.23917/bik.v11i2.10577

Nakanishi, S., Hirukawa, H., Shimoda, M., Tatsumi, F., Kohara, K., Obata, A., Okauchi, S., Katakura, Y., Sanada, J., Fushimi, Y., Nishioka, M., Kan, Y., Tomita-Mizoguchi, A., Isobe, H., Iwamoto, H., Takahashi, K., Mune, T., Kaku, K., & Kaneto, H. (2020). Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition. Journal of Diabetes Investigation, 11(3), 633–639. https://doi.org/10.1111/jdi.13185

Nicolo, M. L., Shewokis, P. A., Boullata, J., Sukumar, D., Smith, S., Compher, C., & Volpe, S. L. (2019). Sedentary behavior time as a predictor of hemoglobin A1c among adults aged 40–59 years in the U.S. Nutrition and Health, 25(4), 275–279. https://doi.org/10.1177/0260106019870436

Nurayati, L., & Adriani, M. (2017). Hubungan aktivitas fisik dengan kadar gula darah puasa penderita diabetes melitus tipe 2. Amerta Nutrition, 1(1), 80–87. https://doi.org/10.20473/amnt.v1i2.2017.80-87

Nursalam, Kusnanto, E., Yusuf, A., Kurniawati, N. D., Sukartini, T., Efendi, F., & Kusumaningrum, T. (2020). Pedoman penyusunan literature dan systematic review. Fakultas Keperawatan Universitas Airlangga.

Oshima, S., & Cao, Z. B. (2015). Physical activity, exercise, sedentary behavior and health. Springer.

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2018). Dose-response between frequency of interruption of sedentary time and fasting glucose. Diabetic Medicine, 36(3). https://doi.org/10.1111/dme.13829

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2018). The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. Preventive Medicine Reports, 12, 94–100. https://doi.org/10.1016/j.pmedr.2018.09.002

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2019). Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: A proof-of-concept study. Journal of Science and Medicine in Sport, 22(7), 808–813. https://doi.org/10.1016/j.jsams.2019.01.017

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2020). Impact of free-living pattern of sedentary behavior on intra-day glucose regulation in type 2 diabetes. European Journal of Applied Physiology, 120, 1647–1657. https://doi.org/10.1007/s00421-019-04261-z

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., Dunstan, D., Owen, N., & Chastin, S. F. M. (2020). Diurnal patterns of sedentary time and its interruption are associated with glycemic indices in type 2 diabetes. Journal of Science and Medicine in Sport, 23(11), 1074–1079. https://doi.org/10.1016/j.jsams.2020.06.003

Pawana, I. G. B. A., Aginda, D., Sudhana, I. W., & Adnayana, I. W. (2013). Gambaran aktivitas fisik terhadap kadar gula darah pada penderita diabetes mellitus di wilayah kerja Puskesmas Karangasem I. E-Jurnal Medika Udayana. https://jurnal.harianregional.com/eum/full-15087

Ruissen, M. M., Regeer, H., Landstra, C. P., Jazet, M. S. I., Nijhoff, M. F., Pijl, H., Ballieux, B. E. P. B., Deker, O., Huiman, S. D., & Koning, E. J. P. D. (2021). Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic. BMJ Open Diabetes Research & Care, 9, e002035. https://doi.org/10.1136/bmjdrc-2020-002035

Sam, N., Lestari, H., & Afa, J. R. (2017). Analysis of the relationship between activities of daily living (ADL), physical activity, and dietary compliance with blood glucose levels in diabetes mellitus patients in the working area of Poasia Public Health Center in 2017. Student Scientific Journal of Public Health, 2. https://doi.org/10.3389/fphys.2017.00262

Sardinha, L. B., Magalhães, J. P., Santos, D. A., & Júdice, P. B. (2017). Sedentary patterns, physical activity, and cardiorespiratory fitness in association to glycemic control in type 2 diabetes patients. Frontiers in Physiology, 8, 262. https://doi.org/10.3389/fphys.2017.00262

Smeltzer, S. C., & Bare, B. (2010). Brunner and Suddarth’s textbook of medical-surgical nursing (10th ed.). Lippincott Williams & Wilkins.

Sommers, M. S. (2019). Davis’s diseases & disorders (6th ed.). F. A. Davis Company.

Tremblay, M. S., Aubert, S., Saunders, J. D., Carson, V., Cheung, A. E. L., Chastin, S. F. M., Altenburg, T. M., & Chinapaw, M. J. (2017). Sedentary Behavior Research Network (SBRN)–Terminology Consensus Project process and outcome. International Journal of Behavioral Nutrition and Physical Activity, 14(1), 75. https://doi.org/10.1186/s12966-017-0525-8

World Health Organization. (2020). Physical inactivity a leading cause of disease and disability, warns WHO. World Health Organization.

Yang, L., Kantor, E. D., Nguyen, L. H., Zheng, X., Park, Y., Giovannucci, E. L., Matthews, C. E., Colditz, G. A., & Cao, Y. (2019). Trends in sedentary behavior among the U.S. population, 2001–2016. JAMA, 321(15), 1587–1597. https://doi.org/10.1001/jama.2019.3636

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Published

2025-02-28

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