Kajian metabolit sekunder tanaman ginseng Korea dan Indonesia sebagai peningkat imun tubuh
DOI:
https://doi.org/10.61511/hjtas.v1i1.2023.244Keywords:
bioactive ginsenosides, immune, javanese ginseng, medicinal plants, panax ginseng, talinum triangulareAbstract
Health is essential so viruses and diseases do not quickly attack the body's immune system. The use of plants to maintain health is a form of human relationship with the natural environment. Many medicinal plants can potentially increase the body's immunity, including Ginseng. Various ginseng species, such as Panax Ginseng, are in demand by the public because they have many benefits for preventing and treating various diseases. The active ingredients are amino acids, alkaloids, phenols, proteins, polypeptides, vitamins B1 and B2. P. ginseng roots can increase the activity of effector immune cells, cardiovascular disease, and the central nervous system. Meanwhile, the local Ginseng in Indonesia, Kolesom (Talinum triangulare (Jacq.) Willd), is called Javanese Ginseng, which is still considered a weed even though it contains many bioactive compounds that are rich in benefits. The use of medicinal plants in society was originally a form of traditional knowledge within a community group passed down from generation to generation. With science and technological knowledge increasingly developing, Ginseng has become an exciting study to continue developing and researching. Until now, traditional and modern societies still use Ginseng as a potential plant. Good knowledge from the public regarding the benefits of the ginseng plant requires scientific evidence of this medicinal plant for specific health conditions and diseases that need to be optimized and rationalized.
References
Adeyemi, O., Oyeniyi, O., Mbagwu, H., & Jackson, C. (2011). Evaluation of the gastrointestinal activity of the aqueous root extracts of Talinum triangulare. Research in Pharmaceutical Biotechnology, 3(4), 61-67. https://doi.org/10.5897/RPB.9000015
Agbonon, A., Eklu-Gadegbeku, K., Aklikokou, K., Gbeassor, M., Akpagana, K., Tam, T. W., ... & Foster, B. C. (2010). In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily. Journal of ethnopharmacology, 128(2), 390-394. https://doi.org/10.1016/j.jep.2010.01.039
Aja, P. M., Okaka, A. N. C., Onu, P. N., Ibiam, U., & Urako, A. J. (2010). Phytochemical composition of Talinum triangulare (water leaf) leaves. Pakistan Journal of Nutrition, 9(6), 527-530. https://doi.org/10.3923/pjn.2010.527.530
Andarwulan, N., Batari, R., Sandrasari, D. A., Bolling, B., & Wijaya, H. (2010). Flavonoid content and antioxidant activity of vegetables from Indonesia. Food chemistry, 121(4), 1231-1235. https://doi.org/10.1016/j.foodchem.2010.01.033
Castañeda-Ovando, A., de Lourdes Pacheco-Hernández, M., Páez-Hernández, M. E., Rodríguez, J. A., & Galán-Vidal, C. A. (2009). Chemical studies of anthocyanins: A review. Food chemistry, 113(4), 859-871. https://doi.org/10.1016/j.foodchem.2008.09.001
Chahal, K., & Jha, M. (2020). In-vivo study of Boswellia serrata for modulating immune system and quenching free radicals. Adv in Zoology and Botany, 8(4), 358-68. https://doi.org/10.13189/azb.2020.080408
Choi, J. H., Lee, Y. H., Kwon, T. W., Ko, S. G., Nah, S. Y., & Cho, I. H. (2022). Can Panax ginseng help control cytokine storm in COVID-19?. Journal of Ginseng Research, 46(3), 337-347. https://doi.org/10.1016/j.jgr.2022.02.006
CHOI, K. T. (2008). Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer. Acta Pharmacologica Sinica, 29(9), 1109-1118. https://doi.org/10.1111/j.1745-7254.2008.00869.x
Djauzi, S. (2003). Simposium Peranan Echinacea sebagai Imunomodulator dalam Infeksi Virus dan Bakteri. Jurnal Sains Teknologi Farmasi. 8 (1), 14.
Fajgenbaum, D. C., & June, C. H. (2020). Cytokine storm. New England Journal of Medicine, 383(23), 2255-2273. https://doi.org/10.1056/NEJMra2026131
Handayani, R. T., Arradini, D., Darmayanti, A. T., Widiyanto, A., & Atmojo, J. T. (2020). Pandemi covid-19, respon imun tubuh, dan herd immunity. Jurnal Ilmiah Stikes Kendal, 10(3), 373-380. https://journal.stikeskendal.ac.id/index.php/PSKM/article/view/830.
Harborne, J. B., & Williams, C. A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 55(6), 481-504. https://doi.org/10.1016/S0031-9422(00)00235-1
Hargono, D. (2005). Menambah Energi dengan Bahan Alami. Herba, 35, 18-21.
Hwang, K. H., Kim, H. G., Jang, K., & Kim, Y. J. (2021). Novel Cultivation of six-year-old Korean Ginseng (Panax ginseng) in pot: From Non-Agrochemical Management to Increased Ginsenoside. Journal of Ginseng Research. https://doi.org/10.1016/j.jgr.2021.05.002
Hyun, S. H., Ahn, H. Y., Kim, H. J., Kim, S. W., So, S. H., In, G., ... & Han, C. K. (2021). Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial. Journal of Ginseng Research, 45(1), 191-198. https://doi.org/10.1016/j.jgr.2020.08.003
Hyun, S. H., Kim, S. W., Seo, H. W., Youn, S. H., Kyung, J. S., Lee, Y. Y., ... & Han, C. K. (2020). Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng. Journal of Ginseng Research, 44(4), 527-537. https://doi.org/10.1016/j.jgr.2020.01.005
Jircas. (2010). Talinum triangulare (Jacq.) Willd. (Portulacaceae). http://www.jircas.affrc.go.jp
Kang, S., & Min, H. (2012). Ginseng, the'immunity boost': the effects of Panax ginseng on immune system. Journal of ginseng research, 36(4), 354. https://doi.org/10.5142%2Fjgr.2012.36.4.354
Khoirunnisa, I., & Sumiwi, S. A. (2019). Peran flavonoid pada berbagai aktivitas farmakologi. Farmaka, 17(2), 131-142. https://doi.org/10.24198/jf.v17i2.21922.g11628
Kim, D. H. (2002). Herbal medicines are activated by intestinal microflora. Natural Product Sciences, 8(2), 35-43. https://kmbase.medric.or.kr/KMID/0620720020080020035
Kim, D. H. (2012). Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. Journal of ginseng research, 36(1), 1. http://dx.doi.org/10.5142/jgr.2012.36.1.1.
KOHDA, H., YAMAOKA, Y., MORINAGA, S., ISHAK, M., & DARISE, M. (1992). Saponins from Talinum triangulare. Chemical and pharmaceutical bulletin, 40(9), 2557-2558. https://doi.org/10.1248/cpb.40.2557
Kusnul, Z. (2020). Infeksi Covid-19 Dan Sistem Imun: Peran Pengobatan Herbal Berbasis Produk Alam Berkhasiat: Covid-19 Infection And The Immune System: The Role Of Herbal Medicine Based On Nutritious Natural Products. Jurnal Ilmiah Pamenang, 2(2), 25-30. https://doi.org/10.53599/jip.v2i2.72
Lee, D. Y., Jeong, Y. T., Jeong, S. C., Lee, M. K., Min, J. W., Lee, J. W., ... & Kim, J. H. (2015). Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from Panax ginseng berry. Journal of microbiology and biotechnology, 25(12), 2011-2015. http://dx.doi.org/10.4014/jmb.1505.05069
Lee, J. W., Choi, B. R., Kim, Y. C., Choi, D. J., Lee, Y. S., Kim, G. S., ... & Lee, D. Y. (2017). Comprehensive profiling and quantification of ginsenosides in the root, stem, leaf, and berry of Panax ginseng by UPLC-QTOF/MS. Molecules, 22(12), 2147. https://doi.org/10.3390/molecules22122147
Lestari, I. C. (2020). Potensi Herbal Sebagai Immunomodulator. Jurnal Kedokteran Ibnu Nafis, 9(2), 33-44. https://doi.org/10.30743/jkin.v9i2.85
Liao, D. Y., Chai, Y. C., Wang, S. H., Chen, C. W., & Tsai, M. S. (2015). Antioxidant activities and contents of flavonoids and phenolic acids of Talinum triangulare extracts and their immunomodulatory effects. Journal of food and drug analysis, 23(2), 294-302. https://doi.org/10.1016/j.jfda.2014.07.010
Mualim, L. (2012). Produksi dan kualitas kolesom dengan pemupukan organik dan inorganik. Disertasi. Sekolah Pascasarjana. Institut Pertanian Bogor. Bogor.
Muthia, R., & Astuti, K. I. (2018). Efek imunomodulator infusa umbi bawang dayak (Eleutherina palmifolia L. Merr) dengan metode bersihan karbon. Jurnal Pharmascience, 5(1). http://dx.doi.org/10.20527/jps.v5i1.5787
Oliynyk, S., & Oh, S. (2013). Actoprotective effect of ginseng: improving mental and physical performance. Journal of ginseng research, 37(2), 144. https://doi.org/10.5142%2Fjgr.2013.37.144
Park, S. J., Lim, K. H., Noh, J. H., Jeong, E. J., Kim, Y. S., Han, B. C., ... & Moon, K. S. (2013). Subacute oral toxicity study of Korean red ginseng extract in Sprague-Dawley rats. Toxicological research, 29, 285-292. https://doi.org/10.5487/TR.2013.29.4.285
Park, E. H., Yum, J., Ku, K. B., Kim, H. M., Kang, Y. M., Kim, J. C., ... & Seo, S. H. (2014). Red Ginseng-containing diet helps to protect mice and ferrets from the lethal infection by highly pathogenic H5N1 influenza virus. Journal of ginseng research, 38(1), 40-46. https://doi.org/10.1016/j.jgr.2013.11.012
Park, H. Y., Lee, S. H., Lee, K. S., Yoon, H. K., Yoo, Y. C., Lee, J., ... & Park, S. R. (2015). Ginsenoside Rg1 and 20 (S)-Rg3 induce IgA production by mouse B cells. Immune Network, 15(6), 331-336. https://doi.org/10.4110/in.2015.15.6.331
Pertiwi, R., Notriawan, D., & Wibowo, R. H. (2020). Pemanfaatan tanaman obat keluarga (toga) meningkatkan imunitas tubuh sebagai pencegahan covid-19. Dharma Raflesia: Jurnal Ilmiah Pengembangan Dan Penerapan IPTEKS, 18(2), 110-118. https://doi.org/10.33369/dr.v18i2.12665
Ratan, Z. A., Youn, S. H., Kwak, Y. S., Han, C. K., Haidere, M. F., Kim, J. K., ... & Cho, J. Y. (2021a). Adaptogenic effects of Panax ginseng on modulation of immune functions. Journal of ginseng research, 45(1), 32-40. https://doi.org/10.1016/j.jgr.2020.09.004.
Ratan, Z. A., Haidere, M. F., Hong, Y. H., Park, S. H., Lee, J. O., Lee, J., & Cho, J. Y. (2021b). Pharmacological potential of ginseng and its major component ginsenosides. Journal of ginseng research, 45(2), 199-210. https://doi.org/10.1016/j.jgr.2020.02.004
Riyana, A., Mudigdo, A., & Wasita, B. (2019, June). The effects of ginseng java roots (Talinum paniculatum) extract on Malondialdehyde (MDA) levels in male white sprague dawley rats with forced swimming test model. In IOP Conference Series: Materials Science and Engineering (Vol. 546, No. 6, p. 062025). IOP Publishing. https://doi.org/10.1088/1757-899X/546/6/062025
Sartini, S., & Usman, M. (2014). Uji Anti Mikroba Ekstrak Akar Som Jawa (Tanilum paniculatum, Jacq.(Gaertn)). BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan), 1(1), 18-26. https://doi.org/10.31289/biolink.v1i1.15
Shin, B. K., Kwon, S. W., & Park, J. H. (2015). Chemical diversity of ginseng saponins from Panax ginseng. Journal of ginseng research, 39(4), 287-298. http://dx.doi.org/10.1016/j.jgr.2014.12.005
Silalahi, M. (2022). Talinum paniculatum (Jacq.) Gertn (Kajian Pemanfaatannya sebagai Bahan Pangan dan Bioaktivitasnya. Jurnal Pro-Life, 9(1), 289-299. https://doi.org/10.33541/jpvol6Iss2pp102
Siswandono. (2014). Pengembangan Obat Baru Edisi Pertama. Surabaya (ID): Airlangga University Press. https://opac.perpusnas.go.id/DetailOpac.aspx?id=886907
Susanti, H., Aziz, S. A., Melati, M., & Susanto, S. (2012). Dinamika kandungan protein pucuk kolesom (Talinum triangulare (Jacq.) Willd) pada berbagai dosis pupuk Urea+ KCl dan interval panen. In Prosiding Simposium dan Seminar Bersama PERAGI-PERHORTIPERIPI-HIGI Mendukung Kedaulatan Pangan dan Energi yang Berkelanjutan (pp. 67-72). https://repository.ipb.ac.id/jspui/bitstream/123456789/59904/2/cover%20simber.pdf
Susanti, H., Aziz, S. A., & Melati, M. (2008). Produksi biomassa dan bahan bioaktif kolesom (Talinum triangulare (Jacq.) Willd) dari berbagai asal bibit dan dosis pupuk kandang ayam. Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy), 36(1). https://doi.org/10.24831/jai.v36i1.1346.
Susanti, H., Susanto, S., Azis, S. A., & Melati, M. (2014). Respon fisiologis dan produksi pucuk kolesom (Talinum triangulare (Jacq.) Willd) terhadap aplikasi pupuk nitrogen+ kalium melalui tanah dan daun. Ziraa'ah Majalah Ilmiah Pertanian, 39(2), 37-44. http://dx.doi.org/10.31602/zmip.v39i2.62
Tang, L., Yin, Z., Hu, Y., & Mei, H. (2020). Controlling cytokine storm is vital in COVID-19. Frontiers in immunology, 11, 570993. https://doi.org/10.3389/fimmu.2020.570993
Tansakul, P., Shibuya, M., Kushiro, T., & Ebizuka, Y. (2006). Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS letters, 580(22), 5143-5149. https://doi.org/10.1016/j.febslet.2006.08.044
Wang, L., Nie, Z. K., Zhou, Q., Zhang, J. L., Yin, J. J., Xu, W., ... & Liang, S. (2014). Antitumor efficacy in H22 tumor bearing mice and immunoregulatory activity on RAW 264.7 macrophages of polysaccharides from Talinum triangulare. Food & function, 5(9), 2183-2193. https://doi.org/10.1039/C4FO00202D
Wulansari, R., Palupi, D. H. S., & Puspitaningrum, I. (2016). Efek Imunomodulator Ekstrak Etanol Daun Som Jawa (Talinum Triangulare (Jacq.) Willd) Pada Mencit Jantan Galur Swiss. Media Farmasi Indonesia, 11(1), 1004-1013. https://mfi.stifar.ac.id/MFI/article/view/149/121
Yeh, S. H., Hsu, W. K., Chang, Z. Q., Wang, S. H., Hsieh, C. W., Liou, G. G., ... & Tsai, M. S. (2021). Purification and characterization of fractions containing polysaccharides from Talinum triangulare and their immunomodulatory effects. Processes, 9(4), 709. https://doi.org/10.3390/pr9040709
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